Downregulation of dual-specificity phosphatase 1 (DUSP1) in post-mortem brain white matter in progressive multiple sclerosis

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dc.contributor.authorOró-Nolla, Martí
dc.contributor.authorSun, Melody Cui
dc.contributor.authorReilly, Thomas
dc.contributor.authorAnandarajah, Julia
dc.contributor.authorOtálora-Alcaraz, Almudena
dc.contributor.authorCostelloe, Lisa
dc.contributor.authorKearney, Hugh
dc.contributor.authorMagee, Richard
dc.contributor.authorNolan, Yvonne M
dc.contributor.authorDowner, Eric J
dc.contributor.funderConsortium of National and University Libraries
dc.date.accessioned2026-05-18T15:00:02Z
dc.date.available2026-05-18T15:00:02Z
dc.date.issued2026-03-12
dc.description.abstractOBJECTIVE: Dual-specificity phosphatase 1 (DUSP1) is a negative regulator of mitogen-activated protein kinase (MAPK) activity, and a player in the control of glial function. Several disease models have identified that the expression of DUSP1 is altered in tissue samples, which may contribute to disease pathogenesis. Using post-mortem brain tissue from a cohort of progressive multiple sclerosis (MS) cases, this study set out to determine if the expression of DUSP1 is altered in the brain in MS. METHODS: We employed the use of a combination of PCR, western immunoblotting and immunohistochemical analysis to profile the expression of DUSP1. RESULTS: Data presented herein indicate that DUSP1 is significantly downregulated at gene and protein level in MS white matter tissue, when compared to samples from a non-MS control cohort. We also identify that DUSP1 is expressed on Iba1 + cells in the brain and that ITGAM (CD11b) expression is elevated in white matter in progressive MS. CONCLUSIONS: These findings provide evidence that DUSP1 is dysregulated centrally in CNS white matter in progressive MS.en
dc.description.statusPeer revieweden
dc.description.versionPublished Version
dc.format.extent5
dc.format.extent744294
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid338
dc.identifier.authororcidOró-Nolla, Martí
dc.identifier.authororcidSun, Melody Cui
dc.identifier.authororcidReilly, Thomas
dc.identifier.authororcidAnandarajah, Julia
dc.identifier.authororcidOtálora-Alcaraz, Almudena
dc.identifier.authororcidCostelloe, Lisa
dc.identifier.authororcidKearney, Hugh
dc.identifier.authororcidMagee, Richard
dc.identifier.authororcidNolan, Yvonne M§0000-0003-2426-234X
dc.identifier.authororcidDowner, Eric J
dc.identifier.citationOró-Nolla, M., Sun, M. C., Reilly, T., Anandarajah, J., Otálora-Alcaraz, A., Costelloe, L., Kearney, H., Magee, R., Nolan, Y. M. and Downer, E. J. (2026) 'Downregulation of dual-specificity phosphatase 1 (DUSP1) in post-mortem brain white matter in progressive multiple sclerosis', Neurological Sciences, 47(4), 338. https://doi.org/10.1007/s10072-026-08944-2
dc.identifier.doi10.1007/s10072-026-08944-2
dc.identifier.issn1590-1874
dc.identifier.issued4
dc.identifier.journaltitleNeurological Sciences
dc.identifier.otherPubMedCentral: PMC12979298
dc.identifier.otherORCID: /0000-0003-2426-234X/work/215062486
dc.identifier.urihttps://hdl.handle.net/10468/18779
dc.identifier.volume47
dc.language.isoen
dc.publisherSpringer Nature
dc.rights© 2026, the Authors.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectDUSP1
dc.subjectMultiple sclerosis
dc.subjectWhite matter
dc.subjectMicroglia/macrophages
dc.subject[Medicine]
dc.subject[APCMicrobiome]
dc.titleDownregulation of dual-specificity phosphatase 1 (DUSP1) in post-mortem brain white matter in progressive multiple sclerosisen
dc.typeArticle (Peer reviewed)
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