Downregulation of dual-specificity phosphatase 1 (DUSP1) in post-mortem brain white matter in progressive multiple sclerosis
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Date
2026-03-12
Authors
Oró-Nolla, Martí
Sun, Melody Cui
Reilly, Thomas
Anandarajah, Julia
Otálora-Alcaraz, Almudena
Costelloe, Lisa
Kearney, Hugh
Magee, Richard
Nolan, Yvonne M
Downer, Eric J
Journal Title
Journal ISSN
Volume Title
Publisher
Springer Nature
Published Version
Abstract
OBJECTIVE: Dual-specificity phosphatase 1 (DUSP1) is a negative regulator of mitogen-activated protein kinase (MAPK) activity, and a player in the control of glial function. Several disease models have identified that the expression of DUSP1 is altered in tissue samples, which may contribute to disease pathogenesis. Using post-mortem brain tissue from a cohort of progressive multiple sclerosis (MS) cases, this study set out to determine if the expression of DUSP1 is altered in the brain in MS. METHODS: We employed the use of a combination of PCR, western immunoblotting and immunohistochemical analysis to profile the expression of DUSP1. RESULTS: Data presented herein indicate that DUSP1 is significantly downregulated at gene and protein level in MS white matter tissue, when compared to samples from a non-MS control cohort. We also identify that DUSP1 is expressed on Iba1 + cells in the brain and that ITGAM (CD11b) expression is elevated in white matter in progressive MS. CONCLUSIONS: These findings provide evidence that DUSP1 is dysregulated centrally in CNS white matter in progressive MS.
Description
Keywords
DUSP1 , Multiple sclerosis , White matter , Microglia/macrophages , [Medicine] , [APCMicrobiome]
Citation
Oró-Nolla, M., Sun, M. C., Reilly, T., Anandarajah, J., Otálora-Alcaraz, A., Costelloe, L., Kearney, H., Magee, R., Nolan, Y. M. and Downer, E. J. (2026) 'Downregulation of dual-specificity phosphatase 1 (DUSP1) in post-mortem brain white matter in progressive multiple sclerosis', Neurological Sciences, 47(4), 338. https://doi.org/10.1007/s10072-026-08944-2